健康的生活方式可降低有妊娠高血壓遺傳傾向婦女的心血管風(fēng)險(xiǎn)

Sang?Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

摘要

妊娠期高血壓疾病的遺傳風(fēng)險(xiǎn)與動(dòng)脈粥樣硬化性心血管疾病的發(fā)展有關(guān)。然而，生活方式和代謝綜合征對(duì)動(dòng)脈粥樣硬化性心血管疾病的影響尚未得到評(píng)估。在這里，我們?cè)u(píng)估了這些因素與有妊娠期高血壓疾病遺傳風(fēng)險(xiǎn)的女性動(dòng)脈粥樣硬化性心血管疾病之間的長(zhǎng)期關(guān)聯(lián)。我們使用來(lái)自大規(guī)模GWAS的全基因組多基因風(fēng)險(xiǎn)評(píng)分來(lái)評(píng)估妊娠期高血壓疾病的遺傳風(fēng)險(xiǎn)。動(dòng)脈粥樣硬化性心血管疾病的發(fā)生率根據(jù)遺傳風(fēng)險(xiǎn)、生活方式和代謝綜合征來(lái)評(píng)估。妊娠期高血壓疾病遺傳風(fēng)險(xiǎn)高的個(gè)體發(fā)生動(dòng)脈粥樣硬化性心血管疾病的幾率比遺傳風(fēng)險(xiǎn)低的個(gè)體高53.0%。然而，在高遺傳風(fēng)險(xiǎn)組（前20%）中，通過(guò)維持理想的代謝綜合征狀態(tài)和健康的生活方式，發(fā)生動(dòng)脈粥樣硬化性心血管疾病的風(fēng)險(xiǎn)降低了64.6%，在低遺傳風(fēng)險(xiǎn)組（后20%）中，這一風(fēng)險(xiǎn)降低了65.4%。這些發(fā)現(xiàn)強(qiáng)調(diào)，保持健康的生活方式對(duì)降低動(dòng)脈粥樣硬化性心血管疾病的風(fēng)險(xiǎn)同樣有效，而不依賴于妊娠期高血壓疾病的遺傳風(fēng)險(xiǎn)。

本文章由計(jì)算機(jī)程序翻譯，如有差異，請(qǐng)以英文原文為準(zhǔn)。

Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy.

求助全文

通過(guò)發(fā)布文獻(xiàn)求助，成功后即可免費(fèi)獲取論文全文。 去求助

相關(guān)文獻(xiàn)

二甲雙胍通過(guò)HDAC6和FoxO3a轉(zhuǎn)錄調(diào)控肌肉生長(zhǎng)抑制素誘導(dǎo)肌肉萎縮

Min Ju Kang, Ji Wook Moon, Jung Ok Lee, Ji Hae Kim, Eun Jeong Jung, Su Jin Kim, Joo Yeon Oh, Sang Woo Wu, Pu Reum Lee, Sun Hwa Park, Hyeon Soo Kim

具有疾病敏感單倍型的非親屬供體臍帶血移植后的1型糖尿病

Kensuke Matsumoto, Taisuke Matsuyama, Ritsu Sumiyoshi, Matsuo Takuji, Tadashi Yamamoto, Ryosuke Shirasaki, Haruko Tashiro

來(lái)源期刊

期刊介紹： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.

期刊最新文獻(xiàn)

Real-space observation of the dissociation of a transition metal complex and its concurrent energy redistribution Selection of self-assembled configurational isomers from a dynamic library via a multivariant optimization process Synthesis of hexagonal boron arsenide nanosheets for low-power consumption flexible memristors Vat photopolymerization of stretchable foam with highly entangled and crosslinked structures Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach

相關(guān)知識(shí)

妊娠高血壓可增加后期心血管事件風(fēng)險(xiǎn)
警惕┃高齡妊娠風(fēng)險(xiǎn)大！做好這些，降低生育風(fēng)險(xiǎn)！
家族遺傳與心血管風(fēng)險(xiǎn)：早知早防，安心生活
妊娠期高血壓
妊娠期高血壓健康宣教ppt.pptx
妊娠期高血壓疾病的危害及預(yù)防
妊娠期高血壓疾病的管理與預(yù)防
妊娠高血壓風(fēng)險(xiǎn)究竟有多大？丨健康課堂
妊娠高血壓的病因
妊娠高血壓剖腹產(chǎn)風(fēng)險(xiǎn)

網(wǎng)址: 健康的生活方式可降低有妊娠高血壓遺傳傾向婦女的心血管風(fēng)險(xiǎn) http://www.gysdgmq.cn/newsview1318009.html