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環(huán)境健康研究組

來源:泰然健康網(wǎng) 時(shí)間:2024年12月29日 09:56

研究領(lǐng)域:(1)環(huán)境污染物的生物監(jiān)測(cè);(2)環(huán)境污染物暴露的人群健康效應(yīng)(環(huán)境分子流行病學(xué));(3)環(huán)境污染物的分子毒理機(jī)制(環(huán)境毒理學(xué));(4)暴露和效應(yīng)生物標(biāo)志物的篩選與應(yīng)用。

研究組成員:

副研究員(組長(zhǎng)):黃清育(qyhuang@iue.ac.cn)

副研究員:田美平(mptian@iue.ac.cn)

在讀研究生:

博士生:張西、杜曉妍、南冰茹、Alam

碩士生:高洪影、韓薛婧娉、李富萍、曹美宜

科研項(xiàng)目:

1. 國(guó)家自然科學(xué)基金面上項(xiàng)目:代謝和組蛋白修飾共調(diào)控在砷暴露致學(xué)習(xí)記憶障礙中的作用機(jī)制研究(22076179)

2. 國(guó)家自然科學(xué)基金面上項(xiàng)目:表觀遺傳調(diào)控在PFCs干擾雄性生殖內(nèi)分泌中的作用機(jī)制(21677142)

3. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目:砷暴露對(duì)精子組蛋白修飾的影響及其男(雄)性生殖毒性機(jī)制研究(21307127)

4. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目:鄰苯二甲酸酯側(cè)鏈長(zhǎng)度與雄性生殖毒性的相關(guān)性及分子機(jī)制研究(21307126)

5. 福建省自然科學(xué)基金面上項(xiàng)目:組蛋白修飾在PFOS干擾睪丸類固醇激素合成中的作用機(jī)制研究(2019J01138)

6. 福建省自然科學(xué)基金面上項(xiàng)目:基于表觀遺傳(組蛋白修飾)的 PM2.5雄性生殖毒性機(jī)制研究(2015J01066)

7. 福建省自然科學(xué)基金面上項(xiàng)目:谷胱甘肽轉(zhuǎn)移酶家族基因(表觀)遺傳因素及典型環(huán)境致癌物暴露與肝癌易感性研究(2017J0102)

8. 中國(guó)科學(xué)院城市環(huán)境研究所青年人才領(lǐng)域前沿項(xiàng)目:慢性PM2.5暴露對(duì)機(jī)體內(nèi)源性代謝物的影響及其誘發(fā)代謝紊亂相關(guān)疾病的風(fēng)險(xiǎn)研究(IUEQN201301)

近五年代表論著:

1. Huang Q*, Liu L, Wu Y, Wang X, Luo L, Nan B, Zhang J, Tian M, Shen H. Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. Environ. Int. 2019, 132: 105066.
2. Huang Q, Hu D, Wang X, Chen Y, Wu Y, Pan L, Li H, Zhang J, Deng F, Guo X, Shen H. The modification of indoor PM2.5 exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis. Environ. Int. 2018, 121: 1243-1252.
3. Huang Q, Xi G, Alamdar A, Zhang J, Shen H. Comparative proteomic analysis reveals heart toxicity induced by chronic arsenic exposure in rats. Environ. Pollut. 2017, 229: 210-218.
4. Alamdar A, Tian M, Huang Q*, Du X, Zhang J, Liu L, Shah STA, Shen H. Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic. Ecotoxicol. Environ. Saf. 2019, 170: 513-520.
5. Alamdar A, Xi G, Huang Q*, Tian M, Eqani SAMAS, Shen H. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation. Toxicol. Appl. Pharmacol. 2017, 326: 7-14.
6. Huang Q*, Luo L, Alamdar A, Zhang J, Liu L, Tian M, Eqani SA, Shen H. Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity. Sci. Rep. 2016, 6: 32518.
7. Meiping Tian*, Benhua Zhao, Francis L. Martin, Camilo L.M. Morais, Liangpo Liu, Qingyu Huang, Heqing Shen*. Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure. Environment International 2020, 105313.
8. Meiping Tian, Liangpo Liu, Jie Zhang, Qingyu Huang, Heqing Shen. Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: A pilot study. Chemosphere 2019, 220: 459-467.
9. Meiping Tian*, Xi Zhang, Liangpo Liu, Heng Wang, Jie Zhang, Qingyu Huang, Heqing Shen. Phthalate side chain structures and hydrolysis metabolism associated with their steroidogenesis effects in MLTC-1 Leydig cells. Toxicology letters 2019, 308: 56-64.
10. Meiping Tian, Qingyu Huang, Heng Wang, Francis L Martin, Liangpo Liu, Jie Zhang, Heqing Shen. Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumor cells. Reproductive Toxicology 2019, 83: 54-62.
11. Meiping Tian, Liangpo Liu, Heng Wang, Xiaofei Wang, Francis L. Martin, Jie Zhang, Qingyu Huang, Liangpo Liu, Heqing Shen. Phthalates induce androgenic effects at exposure levels that can be environmentally relevant in humans. Environmental Science & Technology Letters 2018, 5: 232-236.
12. Meiping Tian, Benhua Zhao, Jie Zhang, Francis L. Martin, Qingyu Huang, Liangpo Liu, Heqing Shen. Association of environmental benzo[a]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case-control study. Science of the Total Environment 2016, 541: 1243-1252.

相關(guān)知識(shí)

環(huán)境健康研究中心
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