引用本文

代蘇堯, 楊帆, 胡逸凡, 肖雄. 不同膳食模式與常見慢性非傳染性疾病關系的研究進展[J]. 中華流行病學雜志, 2021, 42(8): 1509-1517

Dai Suyao, Yang Fan, Hu Yifan, Xiao Xiong. Research progress on the relationship between dietary patterns and common noninfectious chronic diseases[J]. Chinese Journal of Epidemiology, 2021, 42(8): 1509-1517.

不同膳食模式與常見慢性非傳染性疾病關系的研究進展

, 楊帆 , 胡逸凡 , 肖雄     

四川大學華西公共衛(wèi)生學院/華西第四醫(yī)院, 成都 610041

收稿日期: 2020-10-16

基金項目: 國家重點研發(fā)計劃（2017YFC0907305，2017YFC0907300）；國家自然科學基金（81903415）；四川省科技廳重點研發(fā)項目（2020YFS0215）；中國營養(yǎng)學會-振東國人體質與健康研究基金（CNS-ZD2020-149）

摘要: 隨著社會的發(fā)展，中國居民膳食模式逐漸趨向西式化，同時疾病譜也逐漸轉變?yōu)槁苑莻魅拘约膊。缛毖孕呐K病和腦卒中。飲食已被視為許多慢性疾病共同且可改變的影響因素。本研究通過檢索中、英文數據庫2015-2020年的文獻，從系統的角度梳理并整合了近年來膳食模式與心血管系統、代謝性疾病、消化系統、運動系統和精神系統的研究結局指標、可能機制和研究結論等。本研究發(fā)現以紅肉及其加工肉類、快餐食品、含糖飲料等為特征的膳食模式是大多數疾病的危險因素，而以蔬菜、水果、全谷物、魚等為特征的膳食模式是大多數疾病的保護因素。本文提出了膳食模式研究中應注意的問題，為后續(xù)的研究以及疾病的預防和干預提供科學依據。

關鍵詞: 膳食模式    慢性非傳染性疾病    

Research progress on the relationship between dietary patterns and common noninfectious chronic diseases

Dai Suyao , Yang Fan , Hu Yifan , Xiao Xiong     

West China School of Public Health and West China Forth Hospital, Sichuan University, Chengdu 610041, China

Fund program: National Key Research and Development Project of China (2017YFC0907305, 2017YFC0907300); National Natural Science Foundation of China (81903415); Key Research and Development Project of Science and Technology Department of Sichuan Province (2020YFS0215); Chinese Nutrition Society-Zhendong Human Fitness and Health Research Fund (CNS-ZD2020-149)

Abstract: With the development of society, the dietary pattern of Chinese residents gradually tends to be Westernized, and the disease spectrum has also been progressively changed into chronic non-communicable diseases like ischemic heart disease and stroke. Diet has been recognized as a common and modifiable factor for many chronic diseases. In this paper, the researches on dietary patterns and common chronic non-communicable diseases in recent years were summarized by searching the literature in Chinese and English databases in the past five years (2015-2020). This research integrated the outcome indicators, possible mechanisms, and research conclusions of dietary patterns and cardiovascular system, metabolic diseases, digestive system, locomotor system, and mental system in the past five years from the perspective of the human system. Dietary patterns characterized by red meat and processed meats, fast foods, sugary beverages were identified as risk factors for most diseases. In contrast, nutritional patterns characterized by vegetables, fruits, whole grains, fish were protective factors for most conditions. Meanwhile, it also put forward some problems that should be paid attention to in studying dietary patterns to provide a scientific basis for the follow-up research and the prevention and intervention of diseases.

Key words: Dietary pattern    Noninfectious chronic disease    

在過去20年里，隨著零售業(yè)和食品業(yè)的迅速發(fā)展，中國居民的飲食逐漸趨向“西式”及“現代化”[1]。人們更傾向于食用方便快捷的加工類食品或快餐，這些食品往往具有高油高糖的特點[2-3]。在疾病負擔方面，根據2019年最新疾病負擔研究數據顯示，自1990年以來，非傳染性疾病造成的傷殘損失壽命年比例顯著增加，其中腦卒中和缺血性心臟病為引起傷殘調整壽命年的前三位病因[4]。全球近1/5的死亡與不良飲食有關，飲食被公認為許多慢性非傳染性疾病的共同且可改變的影響因素[5]，在慢性病的防治中扮演著重要角色。

傳統的營養(yǎng)流行病學研究主要關注單一營養(yǎng)素或食物的影響。近年來，膳食模式分析在營養(yǎng)流行病學中的應用逐漸興起[6]。膳食模式是指日常飲食中各種食物的數量及其在膳食中的相對構成[7]。膳食模式研究將食物、營養(yǎng)素作為整體進行研究，與傳統的營養(yǎng)流行病學研究相比，有如下優(yōu)勢：①能綜合考慮各種食物和營養(yǎng)素間可能存在的相互作用；②某些營養(yǎng)素（如鉀和鎂）之間存在高度關聯，因此很難檢測它們各自的影響，而膳食模式以飲食行為為基礎，這種共線性可以發(fā)揮優(yōu)勢；③單一營養(yǎng)素的作用可能太小而無法檢測，但包含在飲食模式中的多種營養(yǎng)素的累積作用可能增大到足以被檢測到[8]；④膳食模式的研究方法更有助于營養(yǎng)干預如制定膳食指南，因為膳食模式比單一食物或營養(yǎng)素更容易讓公眾理解并實踐，因此更具有公共衛(wèi)生意義[6, 9]。

為明確常見膳食模式對人體系統健康的全面影響以及為今后膳食模式相關研究提供方向和指導，本研究通過檢索中、英文數據庫2015-2020年的文獻，對有關膳食模式與常見慢性非傳染性疾病的關系進行梳理，并以幾個主要系統疾病為切入點展開探討。

1. 膳食模式：膳食模式尚無確定的分類方法，不同國家和地區(qū)分類模式不一樣。因此本文根據不同分類方法確定的膳食模式進行描述，目前常用的分類方法有先驗法、后驗法以及混合法。

（1）先驗法：由國際組織或各國相關領域專業(yè)人士制定的對個體食物攝入定量評分的量表，用于綜合評價個體的膳食攝入情況與某種膳食指南或科學飲食建議的一致情況，如地中海飲食評分、健康飲食指數（Healthy Eating Index，HEI）、國際膳食質量指數（Diet Quality Index，DQI）、膳食平衡指數（Diet Balance Index，DBI）、飲食控制高血壓（Dietary Approaches to Stop Hypertension，DASH）評分等。目前研究中較常使用的膳食指數有替代健康飲食指數（Alternative Healthy Eating Index，AHEI）、地中海飲食評分、DASH評分等。幾乎所有膳食指數的正向指標都包括蔬菜、水果、豆類，但也有不同的側重點。見表 1。AHEI-2010強調多不飽和脂肪酸的高攝入量，DASH飲食關注鈉、低脂奶制品的攝入，而地中海飲食強調不飽和脂肪酸、橄欖油和魚類的攝入，但并不像AHEI-2010和DASH飲食那樣限制鈉的攝入量。由表 1可知，除了DBI是依據《中國居民膳食指南》建立的，其余指數大部分基于歐美人群的飲食指南、預防特定疾病的指南或已知健康的飲食模式構建的，在應用和解釋膳食指數評分時，需要考慮膳食指數的依據、包含條目、截斷值類型、取值類型、是否包含總能量攝入及能量是否需要校正、是否需要分性別或年齡計算、各條目權重等[10]，因此在評價研究人群的膳食質量需要結合研究目的和數據類型綜合考慮進行選擇。目前已有不少研究將DASH評分、地中海飲食評分、HEI評分應用于亞洲人群研究中[11-13]。

表 1 常見先驗膳食評分歸納表

（2）后驗法：采用數據驅動的方法如主成分分析、因子分析等提取出的膳食模式。如西方模式、謹慎模式[20]，由于研究數據來源不同以及方法的主觀抉擇，各膳食模式的命名及主要成分間存在交叉和不同。西方模式大多以紅肉及精加工肉類、含糖飲料、高脂奶制品、精制谷物為特征，常見于歐美地區(qū)。謹慎模式大多以蔬菜、水果、全谷物、魚類等為特征，常見于亞洲地區(qū)。由于后驗膳食提取旨在最大化解釋食物的變異，因此可以提取出具有當地特色的膳食模式，但往往不具有外推性。目前已有研究基于中國人群的數據提取膳食模式，Li和Shi[3]基于中國健康與營養(yǎng)調查數據使用主成分分析提取出傳統膳食模式和現代膳食模式；而Yu等[21]基于中國慢性病前瞻性研究數據使用因子分析提取出傳統北方膳食模式和現代膳食模式。

（3）混合法：結合數據驅動和先驗知識得到的膳食模式，如降秩回歸法。降秩回歸法根據先驗知識選擇與感興趣的疾病結局有關的指標（如營養(yǎng)素或者生化指標）作為反應變量，并采用數據驅動的方法提取能最大限度解釋反應變量變異的膳食模式，更直接地將膳食模式與感興趣的疾病聯系起來[22]。不同于描述性研究，在分析流行病學中關注的是膳食模式與疾病風險的關系，由于單純數據驅動產生的后驗膳食模式旨在解釋食物攝入的變異，往往不能成功地得出預測疾病的飲食模式，而通過降秩回歸法獲得的飲食模式旨在盡量解釋疾病特異性的營養(yǎng)素或者生物標志物的變異，能更好地闡明飲食在疾病病因學中的重要性。Frank等[23]在探究膳食模式與2型糖尿病關系時，根據已有先驗知識即脂聯素、HDL-C和TG與2型糖尿病存在因果關聯，選擇這3種生物標志物作為響應變量納入降秩回歸，通過降維的方法得到能最大程度解釋這3種生物標志物變異的因子（食物）的線性組合，即膳食模式。

2. 膳食模式與疾病：通過文獻檢索，本研究發(fā)現目前國內外膳食模式與疾病的關聯性研究主要集中在心血管系統、代謝性疾病、消化系統、精神系統、運動系統、女性及妊娠相關疾病、泌尿系統疾病等。由于篇幅限制，本研究將根據人體系統進行分類，按照重要性分別對心血管系統、代謝性疾病、消化系統、精神系統、運動系統與膳食模式的研究進行綜述。

雖然不同膳食模式對于各系統的疾病存在不同的影響，但是總體存在一些共性，即以紅肉及精加工肉類、快餐食品、含糖飲料等為特征的膳食模式是疾病的危險因素，整體上呈高熱量、高脂肪、高碳水的特點，如西方模式、炎性膳食模式等；而以蔬菜、水果、全谷物、魚、豆類、堅果等為特征的膳食模式是疾病的保護因素，如謹慎模式、地中海膳食模式等。本文接下來將對膳食模式對不同系統影響的特點進行綜述。

（1）心血管系統：心血管系統中主要研究的結局有高血壓、腦卒中、缺血性心臟病、心肌梗塞、心力衰竭等疾病，而大部分膳食模式研究同時也關注心血管疾病的危險因素如中心性肥胖、血脂異常等。

以紅肉及其制品、快餐、甜食、油、鹽等為特征的膳食模式與心血管疾病及其危險因素呈正相關，此類膳食模式大多呈現高能量、高碳水、高脂肪、高鈉、低鉀、低鈣的特征[24-27]。以蔬菜、水果、堅果、全谷物、豆類等為特征的膳食模式對心血管疾病及其危險因素呈保護作用[24, 26, 28]，此類膳食模式呈低熱量、低脂肪、低碳水化合物和低鈉的特點，包含較多的膳食纖維、維生素和礦物質（鈣、鎂、鉀、硒等）[29]。有研究認為富含蛋白質的膳食模式可以降低血壓[30]，可能是由于來源于食物蛋白質的降壓肽對血壓的調節(jié)作用，也可能通過增加某些氨基酸如?；撬醽硪种蒲芫o張素Ⅱ對Ca2+轉運的作用，從而降低血壓[31]。

DASH飲食作為針對降低高血壓特地提出的膳食，在心血管風險上具有很好的保護作用。DASH飲食強調水果、蔬菜、脫脂或低脂奶制品、谷物、堅果和豆類的攝入，限制紅肉和加工肉類、鹽和含糖飲料的攝入[17]，已被許多國家的糖尿病和心臟協會納入指南進行廣泛推薦。DASH飲食能降低冠心病[25]、高血壓[32-33]、腦卒中[33]、腹主動脈瘤[34]及其相關危險因素的風險[25, 35]，可能與①富含鉀、鈣、鎂等已證明對血漿腎素活性與腎素-血管緊張素系統有影響的礦物質；②含有某些植物化學物如具有抗炎、抗氧化、降低血管生成作用的黃酮類物質；③降低血壓、糖化血紅蛋白和BMI等其他已確定的心血管疾病風險因素等復雜機制有關[35]。地中海飲食雖然不是特地針對心血管疾病提出的膳食模式，但在心血管疾?。ㄈ绺哐獕?、冠心病、心源性猝死）及其危險因素方面也具有保護作用[25, 36-38]，可能是炎癥、腸道菌群等復雜機制共同作用的結果[36]。

（2）代謝性疾?。猴嬍撑c體內能量、糖、脂肪、蛋白質等多種物質代謝有關。目前大量研究均已證明，飲食是代謝性疾病發(fā)生發(fā)展的重要因素之一。在代謝性疾病中，主要研究的結局有2型糖尿病、超重或肥胖、MS、血脂異常等。

與代謝性疾病的發(fā)病有關的膳食模式大多以紅肉及加工肉類、油炸食品、快餐、甜品、精制谷物、酒精等為特征[39-41]，膳食模式整體上呈現高能量、高碳水、高脂肪的特點。而對代謝性疾病發(fā)病呈保護作用的膳食模式大多以蔬菜、水果、乳類及乳制品、全谷物、堅果、魚蝦、禽肉等為特征[3, 42-43]。除共性外，與各疾病相關的膳食模式還呈現一些其他特點。與糖尿病發(fā)病有關的膳食模式大多包含高糖、高油脂食物和紅肉及加工肉類等[44-46]；與肥胖發(fā)病有關的膳食模式大多包含油炸食品、快餐、肉類等脂肪含量高的食物[47-49]；與血脂異常發(fā)病有關的膳食模式大多包含紅肉及加工肉、米飯、甜食等高碳水、高脂肪食物[50-52]；與高尿酸發(fā)病有關的膳食模式大多包含海鮮、內臟、肉類、菌藻等高嘌呤食物[53-55]。

健康膳食模式評分如地中海膳食評分、DASH評分、AHEI與代謝性疾病的發(fā)病呈負相關。地中海飲食可以改善代謝性疾病相關指標包括血糖、血脂、BMI等[44, 56-57]，但Mirmiran等[58]對伊朗2 241名成年人隨訪3年發(fā)現地中海飲食評分與MS無關，可能與非地中海國家和地中海國家存在食物可獲得性、食物營養(yǎng)素構成、食物加工和制備方面的差異有關。DASH飲食能降低高尿酸血癥、2型糖尿病、MS等代謝性疾病風險[44, 54, 59]。AHEI系列評分得分越高，肥胖、MS、糖尿病的患病風險越低[44, 60-61]。

（3）消化系統疾病：由于人類所攝入的食物均在消化系統進行攝入、消化、吸收、排泄，因此消化系統疾病與膳食模式也存在密切關聯。在消化系統中主要研究的結局有胃癌、肝癌、食管癌、非酒精性脂肪肝、結直腸癌等。

以紅肉及精加工肉類、酒為主的膳食模式增加食道癌[62]、非酒精性脂肪肝、結直腸癌等患病風險，而以蔬菜、水果、全谷物為主的膳食模式對該類疾病具有保護作用。Bertuccio等[20]通過Meta分析發(fā)現在富含水果和蔬菜的“謹慎/健康”飲食和富含淀粉類食物、肉類和脂肪的“西式/不健康”飲食之間，胃癌風險的差異高達2倍。多項研究也發(fā)現非酒精性脂肪肝與食用全谷物、豆類、魚、蔬菜和水果呈負相關，而與食用精制谷物、紅肉及加工肉類、油炸食品呈正相關[63-64]。水果、蔬菜與結直腸癌風險呈負相關，而酒類、醬菜及腌制品類、紅肉類及禽肉類、油炸食品和飲料的攝入與結直腸癌的發(fā)生呈正相關[65-66]。Bravi等[67]對24項病例對照研究進行梳理發(fā)現基于水果和蔬菜的飲食模式對上消化道癌癥存在有益作用，而基于肉類及其制品、酒精的模式可能出現不利的作用。

HEI[68-70]、DASH評分[71]、地中海飲食評分[68-70]與消化系統疾病風險呈負相關，即對健康的飲食模式依從性越高，患該類疾病的風險越低。但Li等[69]對494 968名美國人隨訪10年后發(fā)現HEI和調整地中海飲食評分與胃賁門癌或非賁門腺癌無顯著相關性。雖然食管、胃、肝、結直腸等在解剖學上屬于消化系統，且食管和胃屬于鄰近器官，但其與膳食的不同關聯反映了飲食在消化系統各器官中的可能存在不同抗炎、抗氧化能力或其他生物學機制。

（4）精神系統疾?。壕窠】捣矫媾c膳食模式相關的常見研究結局有認知功能受損（障礙）、抑郁癥、阿爾茨海默病、失眠癥等。目前膳食模式已被認為是影響精神系統疾病的重要發(fā)病因素之一。此外，由于精神系統健康與心血管健康間存在很多共病的生理基礎[72]，精神系統疾?。ㄈ缫钟舭Y、認知功能下降等）和心血管疾病間也存在關聯[72]。心腦血管損傷程度與認知功能受損呈正相關，膳食模式也可能通過影響血壓及心腦血管從而損傷認知功能[72]。

以紅肉及其制品、油炸食品、含糖飲料等為特征的膳食模式是精神系統疾病的危險因素。不健康的飲食如高脂飲食、高糖飲食會導致神經退行性變，增加精神系統患病的風險[73-74]。對精神系統疾病有保護作用的膳食模式大多包含蔬菜、水果、全谷物等食物。抑郁、認知功能、阿爾茨海默病與全身炎癥的上調和促氧化-抗氧化平衡的改變密切相關，而蔬菜、水果、魚蝦、堅果中的抗氧化和抗炎物質可能起到保護作用[73, 75-77]。膳食模式可能通過①抗炎和抗氧化機制，產生神經保護作用；②食物中的營養(yǎng)物質對神經營養(yǎng)素的合成、突觸功能和神經發(fā)生有促進作用[78-79]；③改變細胞膜的流動性和通透性[80]；④心腦血管相關的危險因素[81]等復雜的機制對精神系統產生影響。

各類膳食指數相關研究均發(fā)現堅持健康的飲食習慣與精神健康疾病呈負相關。DASH飲食可以降低認知障礙、阿爾茨海默病、失眠癥的發(fā)病風險[73, 82-83]。堅持地中海飲食模式可以降低認知功能受損[82, 84]、阿爾茨海默病[73, 81]、精神障礙[85]、抑郁癥、焦慮癥等疾病[86]的發(fā)病風險。不過Shi等[87]對中國4 852名≥55歲成年人隨訪15年發(fā)現，雖然提取的膳食模式包含與地中海飲食相似的成分如蔬菜、豆類和全谷物，但沒有顯示出對認知功能的保護作用，可能由于膳食模式中沒有魚和堅果這些對認知功能有益的食物成分，這也是地中海飲食的重要特征。

（5）運動系統疾病：研究與膳食模式相關的運動系統結局指標主要有骨骼健康（如骨折、骨質疏松等）和骨骼肌健康（肌肉功能降低、肌肉減少等）兩方面。

以紅肉及精加工肉類、甜品、含糖飲料、零食等為特征的膳食模式是骨骼及肌肉健康的危險因素[88-89]，而對骨骼及肌肉健康有保護作用的膳食模式大多以雞蛋、豆類、奶及奶制品、蔬菜、水果、魚蝦等為特征[88-90]?？赡芘c以下機制有關：①膳食模式中充足的礦物質（鈣、鉀、鎂）及蛋白質對于骨骼健康如骨基質的形成和維持具有促進作用[91]；②食物中的營養(yǎng)成分可以維持人體酸堿平衡，比如鎂和鉀可以緩沖導致骨吸收的酸性條件，防止骨質流失[92]。水果和蔬菜等堿性食物預防酸中毒，保護肌肉質量和力量[93]；③促炎細胞因子會導致破骨細胞的過度激活和成骨細胞活性的降低[94]，而蔬菜中的抗氧化劑如多酚對活性氧具有清除功能，減少氧化應激，從而對骨骼健康起到保護作用。

各先驗健康膳食指數對于骨骼健康的作用仍存在爭議。地中海飲食對骨骼及肌肉有保護作用[93, 95-96]，堅持DASH飲食模式與患骨關節(jié)炎呈負相關[97]。也有研究認為健康指數與運動系統之間關系尚不明確，Craig等[98]通過以往文獻進行系統回顧和證據圖研究認為目前缺乏可靠的證據表明地中海飲食和各個年齡段肌肉骨骼健康（骨折、骨密度、骨質疏松和骨骼肌減少）之間的關系。Monjardino等[99]對1 180名青少年隨訪4年后未發(fā)現地中海飲食、DASH評分和前臂骨密度之間存在關聯，可能由于這些指南通常不是針對運動系統健康提出的，沒有捕捉到對運動系統健康起重要作用的食物組分。同時膳食模式中的食物組分互相作用也有可能抵消了某些食物的效應，比如地中海飲食模式雖然包含蔬菜、水果等堿性物質，但也包括谷類等酸性食物，后者可能抵消前者的堿性作用[99]。

3. 小結：本研究結果提示食用高營養(yǎng)密度的食物如蔬菜、水果、全谷物、魚、豆類等。這些食物富含礦物質、膳食纖維、n-3脂肪酸、抗氧化物等物質，對于維護各大系統的健康均有益處[100]。此外，可以用更健康的油脂來源代替飽和脂肪酸，例如，可以用富含不飽和脂肪酸的植物油如橄欖油代替動物脂肪如豬油。一些零食如爆米花、餅干和糕點也是飽和脂肪酸的重要膳食來源，可以選擇食品加工的油脂來調節(jié)飲食中的脂肪酸[101]。

膳食影響人體健康往往不是單一途徑的，對生理機制的探索一直處于研究中。本研究通過文獻梳理發(fā)現飲食對人體各大系統的影響既存在共性，也各有特點。膳食可能通過影響血壓、血糖-胰島素穩(wěn)態(tài)、血脂和脂蛋白濃度和功能、氧化應激、全身炎癥、血管內皮健康、凝血/血栓、肝臟功能、脂肪細胞功能、心臟功能、代謝消耗、大腦獎勵、體重調節(jié)通路、內臟脂肪、微生物等多種途徑影響心血管疾病和代謝性疾病的發(fā)病風險[102]。在消化系統方面，可能通過致癌/抑癌作用、腸道菌群、膽汁酸分泌、炎癥、氧化應激、腸道屏障功能、脂代謝等途徑影響消化系統健康。在精神系統方面，可能通過影響炎癥反應、氧化應激、神經細胞膜、腦源性神經營養(yǎng)因子、神經遞質、腦血管功能和腸道菌群等途徑產生影響[78, 80]。在運動系統方面，膳食可能通過影響炎癥反應、氧化應激、骨基質的形成和維持、酸堿平衡等機制影響骨骼和肌肉的健康。上述各個系統中膳食模式均提到可能通過全身炎癥和氧化應激來影響疾病的發(fā)生發(fā)展過程[103-104]。高脂肪、高碳水、高蛋白質飲食與促進炎性反應的進展有關。比如以精制谷物、紅肉及加工肉類、西式快餐、內臟、含糖飲料等為特征的西方膳食模式，這類膳食模式富含糖、膽固醇、飽和脂肪酸等，與炎癥水平呈正相關[41, 104]。實驗研究顯示高脂肪、高碳水化合物和高蛋白質等飲食促進炎癥反應過程，炎性細胞因子促進肝臟組織的慢性低度炎性反應過程的發(fā)生發(fā)展[105]，而以蔬菜、水果、全谷物、豆類等為特征的膳食模式具有抗炎、抗氧化的作用[104, 106]。

需要注意的是，在本文中提到以某些食物為特征的膳食模式與某類疾病有關并不是特指某類食物與疾病有關，而是大部分研究關注的膳食模式的特征中提到了這類食物。因為食物本身單獨的效應并不是本研究的研究范疇，而且某類食物的單獨效應可能受到膳食模式中其他食物及食品組成、類型、品種和制備方法等的影響[37]。殷召雪等[107]研究發(fā)現以蔬菜攝入較多為特征的膳食模式與認知功能損傷呈正相關，可能由于我國居民攝入的蔬菜通常是用鹽烹調或者腌制，隨著蔬菜攝入增加鈉鹽的攝入也增加，從而血壓水平上升，導致認知功能受損。

部分研究得出與其他研究不一致的結論時，可以從以下幾方面進行考慮和分析：①暴露的測量方法。大部分研究的膳食調查問卷是自主設計的，未進行信效度檢驗或者信效度不高。同時，基于FFQ的調查問卷很難包含調查對象所攝入的所有食物，不能反映真實的膳食模式；②暴露的測量偏倚。膳食調查中，調查對象往往傾向于高報健康食物的攝入量如水果、蔬菜，而低報一些不健康食物的攝入量如酒；③膳食模式的計算方法。先驗指數評分計算方法、后驗膳食模式因子提取方法、因子旋轉方法、因子得分計算方法等也會影響膳食模式的確定；④研究人群所在地域文化異質性。不同國家、地區(qū)人群的基因異質性、食物的可及性和營養(yǎng)素構成、不同文化對食物的食用偏好以及食品的加工和制備工藝不同都可能會影響飲食的整體健康效益[108]；⑤研究設計方面。橫斷面研究可能存在反向因果，只能說明暴露和結局間存在關聯，而不具有因果推斷的能力；⑥研究對象的選擇。樣本量和納入排除標準均會影響研究結論的解讀和外推性；⑦關聯性分析。通常對膳食模式按照分位數進行劃分，可能存在錯分的情況。對于結局，可能由于未使用金標準判斷存在錯分，或者自報結局不準確的情況。此外，模型的混雜控制不足也可能影響結果。

本研究概述了近年來膳食模式研究的常見方法，并從人體系統的角度梳理并整合了近年來膳食模式與心血管系統、代謝性疾病、消化系統、運動系統和精神系統的研究結局指標、可能機制和研究結論等，本研究發(fā)現以紅肉及其加工肉類、快餐食品、含糖飲料等為特征的膳食模式是大多數疾病的危險因素，而以蔬菜、水果、全谷物、魚等為特征的膳食模式是大多數疾病的保護因素。對于大部分系統，健康的膳食模式（如DASH飲食、地中海飲食等）對人體健康具有保護作用，而少數系統與膳食模式（如運動系統與地中海模式）的結論仍存在爭議，需要臨床試驗和大型前瞻性隊列在不同人群中進行進一步探索。同時本研究也提出了膳食模式研究中應注意的問題，為后續(xù)的研究以及疾病的預防和干預提供科學依據。

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