首頁資訊環(huán)境PM2.5致神經(jīng)系統(tǒng)損傷機制研究進展

環(huán)境PM2.5致神經(jīng)系統(tǒng)損傷機制研究進展

來源：泰然健康網(wǎng) 時間：2025年05月14日 03:59

摘要

細顆粒物（PM2.5）指環(huán)境中空氣動力學直徑≤2.5 μm的大氣顆粒物，其組成成分復雜，粒徑小，數(shù)量多，可隨人體呼吸到達肺泡并沉積，甚至滲透至循環(huán)系統(tǒng)進入全身，引起相應(yīng)的病理改變。流行病學研究結(jié)果表明，PM2.5暴露可增加神經(jīng)退行性疾病的發(fā)病風險。本文從PM2.5誘導神經(jīng)炎癥反應(yīng)、氧化應(yīng)激、細胞凋亡與自噬、細胞DNA損傷和DNA甲基化等方面闡述環(huán)境PM2.5造成中樞神經(jīng)系統(tǒng)損傷的分子機制。

Abstract

Ambient fine particulate matter (PM2.5) refers to particulate matter whose aerodynamic diameter is less than or equal to 2.5 μm in the environment. Its composition is complex, its particle size is small and its quantity is large. PM2.5 can reach the alveoli, deposit with breath, and even infiltrate into the circulatory system, thus causing corresponding pathological changes. Epidemiological study has showed that PM2.5 exposure could increase the risk of neurodegenerative diseases. This review discusses the molecular mechanism of central nervous system dysfunction induced by ambient PM2.5, including neuroinflammatory response, oxidative stress, cellular apoptosis and autophagy, DNA damage and methylation.

關(guān)鍵詞

PM2.5 / 中樞神經(jīng)系統(tǒng) / 神經(jīng)退行性疾病{{custom_keyword}} /

Key words

PM2.5 /central nervous system /neurodegenerative diseases{{custom_keyword}} /

陳月洪，嚴麗莎，壽逸凱，朱驍拯，樊劼，周詩旗，于文磊，胡宇，王歡歡.環(huán)境PM2.5致神經(jīng)系統(tǒng)損傷機制研究進展. 中國藥理學與毒理學雜志. 2019, 33(7): 550-558 https://doi.org/10.3867/j.issn.1000-3002.2019.07.009

CHEN Yue-hong, YAN Li-sha, SHOU Yi-kai, ZHU Xiao-zheng, FAN Jie, ZHOU Shi-qi, YU Wen-lei, HU Yu, WANG Huan-huan .Research progress in mechanism of nervous system injury induced by environmental PM2.5. Chinese Journal of Pharmacology and Toxicology. 2019, 33(7): 550-558 https://doi.org/10.3867/j.issn.1000-3002.2019.07.009