首頁資訊 CSF3R和行動控制對應激與健康飲食關系的調節(jié)作用：應激影響健康行為的個體化模型的初步證據

CSF3R和行動控制對應激與健康飲食關系的調節(jié)作用：應激影響健康行為的個體化模型的初步證據

來源：泰然健康網時間：2024年11月22日 05:30

摘要：

應激在飲食方面的反應因人而異; 有些人在應激下喜歡多吃甜食和其他高熱量食物, 而另一些人則沒有這樣的傾向。這可能與兩種類型的迷走神經系統(tǒng)功能優(yōu)勢性有關：向營養(yǎng)型或興奮型。本研究以14675位中國成年人為樣本, 結合健康行動過程模型和迷走神經支配性理論, 發(fā)現應激顯著預測了健康飲食意向的減少, 以及隨后健康飲食行為的減少。CSF3R基因rs4076431及其連鎖位點rs4498771, rs10752589, rs9660229調節(jié)了應激與健康飲食意向之間的關系, 而行動控制調節(jié)了健康飲食意向與健康飲食行為之間的關系。以rs4076431為例, 應激與健康飲食意向之間的負向關系在AA基因型(向營養(yǎng)型)中比在G等位基因攜帶者(興奮型)中更強。行動控制分數越高, 健康飲食行為越多, 而且該行為越少受到應激和健康飲食意向的影響。基于這些結果我們提出了應激影響健康行為的個體化模型, 應激下的健康管理應考慮生理、行為、情境等多個層面的影響因素。

關鍵詞: 健康飲食, 感知應激, 基因, 迷走神經支配性

Abstract:

A healthy diet is essential to maintaining a healthy lifestyle, yet many factors may hinder a healthy eating plan. Some studies have found that people tend to consume more unhealthy foods to cope with stress. But the opposite findings also exist. Some people under stress may still maintain a healthy diet. The mechanisms by which people make different dietary choices under stress are not yet clear.

This study combined health behavior theories and vagal tone theory and proposed a gene stress interaction model of dietary choice, arguing that different dietary choices under stress may be related to two types of vagal tone: trophotropic or ergotrophic, representing the tendency to regenerate and recover or the tendency to prepare for fight or flight. CSF3R is a granulocyte colony-stimulating factor receptor that is closely associated with chronic psychological stress responses, and its different genotypes may lead to different stress responses, exhibiting the aforementioned tendency toward or away from nutrition. In addition, action control suggested by HAPA (Health Action Process Approach) may also play a critical role in the implementation of healthy eating intentions into healthy eating behaviors.

A sample of 14675 Chinese adults completed genotyping of their saliva samples, as well as questionnaires on perceived stress, action control, and healthy dietary intentions and behaviors. CSF3R was used as a candidate gene reflecting vagal tone due to its proven impact on stress response. Regression analysis was used to test the effect of stress on healthy dietary intentions and behaviors, and the moderating effect of the CSF3R gene and action control.

Results found that stress predicted a significant reduction in healthy dietary intentions and a subsequent reduction in healthy dietary behaviors. The CSF3R gene rs4076431 and its linked loci rs4498771, rs10752589, rs9660229 moderated the relationship between stress and healthy eating intentions, while action control moderated the relationship between healthy eating intentions and behaviors. In rs4076431, for example, the negative relationship between stress and healthy eating intentions was stronger in AA genotype (trophotropic) than the G carriers (ergotrophic). And higher levels of action control were associated with more healthy eating behaviors and less indirect impact of stress on behavior.

These results supported the individual health action against stress model, which may be applied to healthy diet education and stress management. Individual's stress levels reflecting environmental influence, dominance of vagal tone (or genotype) and action control reflecting individual physiological and psychological factors may all have an impact on dietary choices.

Key words: healthy eating, perceived stress, gene, vagal tone

中圖分類號:

B845

網址: CSF3R和行動控制對應激與健康飲食關系的調節(jié)作用：應激影響健康行為的個體化模型的初步證據 http://www.gysdgmq.cn/newsview24805.html