摘要： 環(huán)境內(nèi)分泌干擾物（ endocrine disruptor chemicals，EDCs）在結(jié)構(gòu)上與類(lèi)固醇激素相似，具有擬類(lèi)固醇激素的免疫調(diào)節(jié)功能，可能影響免疫系統(tǒng)及過(guò)敏反應(yīng)。雙酚 A（bisphenol A，BPA）及三氯生（triclosan，TCS）是廣泛添加于生活日用品及餐飲用品的 2種常見(jiàn)酚類(lèi) EDCs。動(dòng)物實(shí)驗(yàn)發(fā)現(xiàn)，生命早期（包括胚胎和嬰幼兒時(shí)期） BPA暴露可能與幼年期呼吸道過(guò)敏性疾病的發(fā)生有關(guān)。同時(shí)流行病學(xué)證據(jù)也顯示， TCS可能與兒童濕疹性皮炎及呼吸道、消化道過(guò)敏性疾病有關(guān)。過(guò)敏性疾病是影響兒童健康的常見(jiàn)疾病，它是致敏原作用于機(jī)體引起的免疫反應(yīng)異常及變應(yīng)性炎癥反應(yīng)所致的一種疾病。 EDCs可通過(guò)影響輔助 T細(xì)胞（ Th1 /Th2）的功能，增加細(xì)胞因子及免疫球蛋白水平，影響免疫系統(tǒng)，可能與過(guò)敏反應(yīng)有關(guān)。該文主要綜述 BPA和 TCS與兒童過(guò)敏性疾病的關(guān)系及相關(guān)發(fā)病機(jī)制。

關(guān)鍵詞: 環(huán)境內(nèi)分泌干擾物, 雙酚 A, 三氯生, 兒童過(guò)敏性疾病

Abstract:

Endocrine disruptor chemicals (EDCs) are similar to steroid hormones in molecular structure, and may have steroid-like disrupting effects on the immune system and influence the risk of allergic diseases. For example, bisphenol A (BPA) and triclosan (TCS) are commonly EDCs existing in the environment, and both BPA and TCS are widely added to daily necessities and catering products. Animal experiments found that prenatal BPA exposure may be associated with higher risk of respiratory allergic diseases in offspring. It was also founda few epidemiological studies that TCS exposure was associated with higher risks of eczema, and allergic disorders in respiratory system and digestive tracts in children. EDCs may increase cytokines and immunoglobulins levelsinterrupting the function of helper T cells (Th1/Th2) so as to affect the immune system, which might be associated with allergic reactions. This review mainly focused on the correlation between EDCs (BPA and TCS) and childhood allergic diseases and the underlying mechanisms.

Key words: endocrine disruptor chemicals, bisphenol A, triclosan, children′s allergic disease

中圖分類(lèi)號(hào): 

R12

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