摘要：

目的 采用meta分析探討口腔健康狀況與認(rèn)知功能障礙發(fā)生風(fēng)險(xiǎn)的相關(guān)性。方法 計(jì)算機(jī)檢索 PubMed、Web of Science、EMBASE、Scopus、知網(wǎng)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、萬方、維普、讀秀數(shù)據(jù)庫中關(guān)于口腔健康狀況與認(rèn)知功能相關(guān)性的隊(duì)列研究,檢索時(shí)限均為建庫至2023年8月。由2名研究者獨(dú)立篩選文獻(xiàn)、提取資料并評(píng)價(jià)納入研究的文獻(xiàn)質(zhì)量, 采用RevMan 5.3及Stata 17.0軟件進(jìn)行meta分析。結(jié)果 共納入34個(gè)隊(duì)列,meta分析結(jié)果顯示,與口腔健康狀況好的老年人相比口腔健康狀況差的老年人發(fā)生認(rèn)知功能障礙的風(fēng)險(xiǎn)增加[RR=1.31, 95%CI(1.18~1.46), P<0.01]。亞組分析結(jié)果顯示,牙周炎/牙周病、后咬合支撐、牙列狀態(tài)、牙齒缺失亞組差異均有統(tǒng)計(jì)學(xué)意義(P<0.05),而在口腔衰弱亞組中, 差異無統(tǒng)計(jì)學(xué)意義[RR=1.32, 95%CI(0.96~1.81), P=0.09],口腔健康狀況與認(rèn)知障礙發(fā)生風(fēng)險(xiǎn)在隨訪時(shí)間>10年亞組差異無統(tǒng)計(jì)學(xué)意義[RR=1.01, 95%CI(0.83~1.23),P=0.90];在隨訪時(shí)間≤10年亞組差異有統(tǒng)計(jì)學(xué)意義[RR=1.48, 95%CI(1.32~1.67), P<0.001];口腔健康狀況與認(rèn)知障礙發(fā)生風(fēng)險(xiǎn)在中等質(zhì)量亞組差異無統(tǒng)計(jì)學(xué)意義[RR=1.05, 95%CI(0.91~1.20), P=0.51];在高質(zhì)量亞組則差異有統(tǒng)計(jì)學(xué)意義[RR=1.35, 95%CI(1.21~1.51), P<0.01]。 結(jié)論 口腔健康狀況與認(rèn)知功能障礙發(fā)生風(fēng)險(xiǎn)具有相關(guān)性。

關(guān)鍵詞: 口腔保健, 老年人, 認(rèn)知功能, Meta分析

Abstract:

Objective To explore the correlation between oral health status and the risk of cognitive dysfunction by meta-analysis. Methods Cohort studies on the correlation between oral health status and cognitive function from inception to August 2023 were searched in PubMed, Web of Science, EMBASE, Scopus, Chinese National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), Wanfang, VIP and Duxiu databases. Two reviewers independently screened literatures, extracted data and evaluated the quality of included studies. Meta-analysis was performed using RevMan 5.3 and Stata 17.0 software. Results A total of 34 cohorts were included. The results of meta-analysis showed that the risk of cognitive impairment in the elderly with poor oral health status was significantly higher than that in the elderly with good oral health status (RR=1.31, 95%CI 1.18-1.46, P<0.01). The results of subgroup analysis showed that there were significant differences in periodontitis disease, posterior occlusal support, dentition status, and tooth loss (P<0.05), but there was no significant difference in the oral frailty (RR=1.32, 95%CI 0.96-1.81, P=0.09). There was no significant difference in the risk of oral health status and cognitive impairment in the subgroup with a follow-up time>10 years (RR=1.01, 95%CI 0.83-1.23, P=0.90), but a significant difference was detected in the subgroup with a follow-up time ≤10 years (RR=1.48, 95%CI 1.32-1.67, P<0.001). There was no significant difference in the risk of oral health status and cognitive impairment in the moderate quality subgroup (RR=1.05, 95%CI 0.91-1.20, P=0.51), but a significant difference was detected in the high quality subgroup (RR=1.35, 95%CI 1.21-1.51, P<0.01). Conclusion Oral health status is associated with the risk of cognitive dysfunction.

Key words: oral health, elderly, cognitive function, meta-analysis

中圖分類號(hào): 

R473.78

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